A Comprehensive Look at the Double Marker Test During Pregnancy


Double marker test is a prenatal test recommended for women during pregnancy. The test checks for any genetic disorder or risk for certain birth defects in the unborn child. 

A double marker test in pregnancy, is conducted during the first trimester and analyses two specific substances for chromosomal abnormalities. 

Women over the age of 35 and having a history of birth defects should consider getting a dual marker test. Levels of substances can help identify the risk of certain birth defects, like Down syndrome.

Types of Pregnancy Hormones Measured

A double marker test includes a blood sample and an ultrasound. The blood sample is taken to look for two hormones—the free beta human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein A (PAPP-A). An ultrasound called a nuchal translucency (NT) scan, examining the clear tissue at the back of the baby’s neck. 

Timing of Tests 

There is a relatively slim window for conducting the dual marker test. Usually, it is conducted near the end of the first trimester or possibly very early in the second trimester. The test is usually done between 11 and 14 weeks. 

This test is a screening test, and it checks only the risk of any genetic disorders. It does not diagnose the problem, and a positive result means you need further testing.

Abnormalities Predicted

Double markers test can predict the abnormalities but not confirm them. It helps detect three primary conditions due to the addition of one or more cells. 

  • The beta HCG test can help in detecting Down syndrome, also known as Trisomy 21. It can cause mental and physical challenges for the newborn. 
  • Other abnormality includes Trisomy 13 (Patau’s syndrome), which can cause severe neurological and physical abnormalities. 
  • Trisomy 18 (Edward’s syndrome) is a severe abnormality linked with heart defects and organ malfunctions. 

The double marker test, though optional, can be beneficial to check for any kind of difficulty in pregnancy. It is conducted near the end of the first trimester of pregnancy. The cost of the test is generally affordable, making it accessible for expecting mothers. It can predict Down syndrome, Patau’s syndrome, and Edward’s syndrome.

Stay on top of your health with routine screenings. Explore affordable packages for Full Body Checkup in Bhubaneswar and take proactive steps to detect health issues early.

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